A Lesson in the Body’s Building Blocks

By W. Gifford-Jones MD and Diana Gifford Not everyone needs to have the knowledge of today’s biochemist. What’s important to know is that there have been extraordinary advances in what scientists now understand about the way the human body works. Their discoveries show it’s the little things that matter. Fifty years ago, the focus was at the level of the cell, understanding its properties and functions. In labs, experiments involved poking and prodding cells to see how they behaved in response. Today, advances in technology make it possible tostudy the building blocks of cells and how they function. Scientists, and now computers, are sequencing DNA at lightening pace. They can study proteins, for example, one at a time, manipulating genetic codes in search of breakthroughs in disease treatments. Among the little things that matter are myriads of chemical and electrical interactions involving lipids, proteins, nucleic acids and carbohydrates. One marvels at this microscopic complexity! One remarkable and very small worker is proline, an amino acid that functions as a building block for proteins. Think of it as an odd piece of Lego requiring combinations with other Lego to make a strong and purposeful structure. While it's not as well-known as some other amino acids, proline is indispensable for the structure and function of collagen, tendons, ligaments, cartilage, and skin. Supplementing with L-proline can be beneficial for individuals with joint problems, as it promotes the repair and regeneration of damaged cartilage and connective tissues. It also aids in reducing joint pain and improving mobility. What does the “L” in front of proline mean when you see it as an ingredient in a supplement? The letter L stands for “levorotatory,” which is a chemistry term indicating the amino acid is in its free form, or not already bonded with a protein molecule. It’s the Lego block on its own, before it sticks together with other building blocks. L-proline promotes good health because it aids in the formation of new collagen and tissue. This means it has an important role in helping heal wounds such as those occurring from surgery, injury, or skin conditions like pressure ulcers. Collagen formation is essential in the maintenance and renewal of cells in other important parts of the body too. Notably, L-proline helps prevent atherosclerosis,the buildup of arterial plaque. This buildup can restrict blood flow, increase the risk of heart attacks and strokes, and contribute to high blood pressure. How does it do it? L-proline works by reducing the capacity for fats to settle down in arterial walls, thereby preventing the progression of atherosclerosis. It also promotes the relaxation of blood vessels, which can help lower blood pressure. Combining L-proline with other heart-healthy nutrients, like vitamin C and lysine, can further enhance its cardiovascular benefits. The combination is a powerful set of antioxidants. Together, they neutralize harmful free radicals, reducing oxidative stress and protecting cells from damage. As we age, collagen production naturally declines, leading to visible signs of aging, such as sagging skin and wrinkles. Choosing a supplement that contains L-proline is part of maintaining skin and arteria elasticity in the context of naturally deteriorating capacity to self-manufacture our own Lego blocks, as we do so easily as younger people. There’s no proven way to stop aging, but ensuring cells are unnecessarily calling it quits is worth every effort. It's fascinating to stop and think about existential questions. Everything we are, including our consciousness, is the result of chemical and electrical interactionsmost of us take for granted. But don’t pause for long. Get active and fuel your body well, so that more healthy building is underway than neglectful destruction. Sign-up at www.docgiff.com to receive our weekly e-newsletter. For comments, contact-us@docgiff.com. Follow us Instagram @docgiff and @diana_gifford_jones